DESCRIPTION

Pyrroloquinoline Quinone (PQQ) is a water-soluble, thermo-stable TAG-quinone, which is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor with molecular weight 374.17 g/mol. PQQ is ubiquitous in nature and found in many dietary sources such as fermented soyabeans, tea, green peppers, parsley, kiwi and human milk.

PQQ acts as potent microbial growth stimulant and diversified role in antibiotics as chief biological control determinant for plant pathogens. It has role in direct electron transfer of bacterial energy transduction and ATP synthesis during oxidation, it has diverse roles in animals like NMDA medicated receptor in neurological injury, repair and improved memory by ERK1/2 pathway. PQQ promotes and improves neonatal development and reproduction involving mitochondrial biogenesis and cell signaling pathways. PQQ plays vital role in liver fibrogenesis and in signal transduction via mitochondrial biogenesis. It has diverse functions in insulin resistance and aging by creation of new mitochondria. In plants PQQ has phosphate solubilizing activities, plant growth promotion, antifungal activities, induces systematic resistance and symbiosis by acting as an antioxidant.

The important roles PQQ plays in human being including:

² Antio‌xidant  

² ‌Increasing quantity and quality of healthy mitochondrion in aging cells

² Boosting immune system

² Scavenging free radicals

² Enhancing the synthesis of Nerve Growth Factor

² Bettering longer sleep and improving moods

² Preventing and treating liver injury

² Improving reproductive ability

² DNA repairing

² Promoting the absorption of amino acids

² Stimulating the synthesis of cell growth factors

² Accelerating the synthesis of glutathione

² Powerful cancer fighter by activating NK cell to ANK cell

Pallas PQQ is produced with advanced fermentation process by Hyphomicrobium sp. which is selected through HTS system. World-leading filtration systems are used to purity PQQ product, and quality control is strictly and precisely obeyed. The purity is over 99% and water solubility is 3.08g/L at 25℃, it’s also a safe product with Non-GMO, Gluten-Free, Allergen-Free and Vegetarian. Pallas PQQ has passed various tests and proved to be very safe.

A. Ames/Reverse Mutation Assay

5000μg/plate, negative
 

B. Chromosomal aberration test in cultured mammalian cells (In vitro)

3750μg/mL, negative
 

C. Chromosomal aberration test in human peripheral blood lymphocytes (In vitro)

3750μg/mL, negative
 

D. Micronucleus test in mice (in vivo)

1,000-2,000mg/kg, no toxicity
 

E. Subchronic oral toxicity study

400mg/kg/day, NOAEL in rats
 

F. Acute Oral Toxicity Study

1,000-2,000mg/kg, no toxicity
 

G. 14-day dose-range

768mg/kg/day, no toxicity
 

H. 28-day Renal Toxicity

700mg/kg/day, no toxicity

I. 13-week Subchronic Oral Toxicity

100mg/kg/day, no toxicity

As a new material, PQQ has been approved as a safe food supplement by FDA and EU, it’s also authorized as the new raw-food material by SFDA. PQQ functions in nutrition and health are coming to be recognized, so it will be widely used in nutraceutical and cosmetic applications based on its powerful functions, good safety and stability.